在寻找植物肿瘤抑制剂时,作者等重新研究了百合科美丽秋水仙(Colchicum speciosum),发现此植物球茎的乙醇提取物对P-388小鼠白血病瘤谱及KB细胞具有显著活性。用以上模型为指示,导致分得有活性的成分为已知的脱羰秋水仙碱(Demecolcine),秋水仙碱(Colchicine)和2-脱甲基秋水仙碱(2-Desmethylcolchine)(Ⅰ)。与经过详细临床前的和在临床已证实的秋水仙碱和脱羰秋水仙碱相反,Ⅰ对肿瘤的抑制活性试验未见报道。据美国国立肿瘤研究所试验,Ⅰ在1～5毫克公斤剂量范围对 Looking for a plant tumor suppressor, the authors re-examined the Colchicum speciosum and found that the ethanol extract of the plant bulbs had significant activity on the P-388 murine leukemia tumor and KB cells. Using the above model as an indicator, the active ingredients were obtained as known Demecolcine, Colchicine and 2-Desmethylcolchine (I). In contrast to the preclinical and clinically proven colchicine and colchicine, the inhibitory activity of I against tumors has not been reported. According to the National Cancer Institute test, Ⅰ in the 1-5 mg kg dose range