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意大利Ceconi等发现,ACEI培哚普利可以部分逆转CAD患者的内皮功能异常。作者入选了参加EUROPA研究的1200例患者,测定其基线的和培哚普利或安慰剂治疗1年以后的血管假性血友病因子(vWf),并通过在体培养人脐静脉内皮细胞,研究了45名健康对照者和87例EUROPA患者的内皮功能。作者还测定了内皮中NO合成酶的蛋白表达/活性和细胞凋亡速度,以及血浆AngⅡ、缓激肽、TNF-α和硝酸盐/亚硝酸盐水平。
Italy Ceconi found that, ACEI perindopril can partially reverse endothelial dysfunction in CAD patients. The authors enrolled 1,200 patients enrolled in the EUROPA study and measured vWf at baseline and after 1 year of treatment with perindopril or placebo. The vWf was measured by in vivo culture of human umbilical vein endothelial cells, Endothelial function was studied in 45 healthy controls and 87 EUROPA patients. The authors also determined the protein expression / activity of NO synthase and the rate of apoptosis in the endothelium, as well as plasma levels of AngII, bradykinin, TNF- [alpha] and nitrate / nitrite.