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目的探讨非酒精性脂肪性肝病患者血清瘦素水平与肝酶学等指标变化的相关性。方法用ELISA法测定血清瘦素水平,结合患者的临床情况及肝脏酶学等指标,采用t检验和相关分析进行数据分析。结果 NAFLD组血清瘦素水平明显高于健康对照组(P<0.001);瘦素水平分别与ALT、AST、GGT、TG、FBG、腰臀比、BMI呈正相关,与HDL-C呈负相关;血清瘦素与腰臀比、ALT、FBG呈独立正相关。结论 NAFLD患者血清瘦素水平升高,与肝脏损伤程度及疾病进展有相关性。
Objective To investigate the correlation between serum leptin level and liver enzymology in patients with non-alcoholic fatty liver disease. Methods The level of serum leptin was measured by ELISA. According to the clinical situation and liver enzymology of the patients, t-test and correlation analysis were used to analyze the data. Results The level of serum leptin in NAFLD group was significantly higher than that in healthy control group (P <0.001). Leptin levels were positively correlated with ALT, AST, GGT, TG, FBG, WHR, BMI and negatively correlated with HDL- Serum leptin and waist-hip ratio, ALT, FBG were independent positive correlation. Conclusions Serum leptin level is elevated in patients with NAFLD, which is related to the degree of liver injury and the progress of the disease.