1957年在加拿大多伦多发现一种口炎及手足疱疹病流行,并证实其病原为病毒。1959年英国伯明翰又出现流行时,才命名为“手足口病’(Hand Foot andMouth Disease;HFMD)。现已证实,手足口病广泛存在地球上的温带地区,如非洲南部、北美洲、欧洲及大洋洲的一些国家多次发生流行。在亚洲近20年来,日本报告最多,自1970年以来曾发生5次大流行,1982年的流行,全日本报告143304例,其次是新加坡 In 1957 in Toronto, Canada found a stomatitis and herpes simplex epidemic, and confirmed that the pathogen is a virus. It was named “Hand Foot andMouth Disease (HFMD)” when Birmingham became popular again in 1959. Hand-foot-mouth disease has now been proven to be widespread in temperate regions of the globe such as southern Africa, North America, Europe and Japan has reported the most in some 20 years in Asia, five major epidemics since 1970 and the 1982 epidemic, with 143,304 Japanese reports in all, followed by Singapore