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目的探讨塞来昔布术前同期放化疗治疗直肠癌的近期疗效。方法前瞻性分析应用塞来昔布辅助放化疗直肠癌35例的临床资料。结果应用塞来昔布术前同期放化疗治疗的直肠癌患者,放疗期间生活质量、手术切除率及保肛率、术后病理消退情况均优于对照组。结论塞来昔布术前同期放化疗治疗直肠癌安全有效,并能提高近期肿瘤缓解率。
Objective To investigate the short-term curative effect of preoperative celecoxib radiotherapy and chemotherapy for rectal cancer. Methods prospective analysis of celecoxib adjuvant radiotherapy and chemotherapy of rectal cancer in 35 cases of clinical data. Results The application of celecoxib preoperative radiotherapy and chemotherapy in rectal cancer patients, quality of life during radiotherapy, surgical resection rate and anal sphincter rate, postoperative pathological regression were better than the control group. Conclusion Preoperative celecoxib radiotherapy and chemotherapy in the treatment of rectal cancer is safe and effective, and can improve the recent tumor response rate.