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目的:设计一种用于复发的胰腺癌和前列腺癌放射治疗的PLDR-IMRT计划。方法:选择10例复发胰腺癌和10例复发前列腺癌患者,每个计划设置10个非共面射野,采用各种优化手段使得计划满足PLDR治疗的要求。并与三维适形(PLDR-3DCRT)计划和旋转调强(PLDR-ARC)计划比较。结果:胰腺癌PLDR-IMRT计划中,每个单独的射野中PTV的平均剂量在17.6cGy到22.4cGy之间,最大剂量的范围从22.9cGy到34.8cGy。前列腺癌病例中,PTV在每个单独的射野中的平均剂量在18.8cGy到22.6cGy之间,最大剂量的范围从24.0cGy到34.7cGy。IMRT计划中危及器官的剂量大大小于三维适形计划,接近旋转调强计划。结论:在脉冲式低剂量率放射治疗中,通过优化的设计,IMRT计划相对于通常使用的3DCRT计划更有优势,在保证靶区剂量的基础上降低了危及器官受量。
OBJECTIVE: To design a PLDR-IMRT program for radiation therapy for recurrent pancreatic and prostate cancer. METHODS: Ten patients with recurrent pancreatic cancer and 10 patients with recurrent prostate cancer were enrolled. Ten non-co-facial fields were planned for each program and various optimization techniques were used to make the plan to meet the requirements of PLDR treatment. And compared with the three-dimensional conformal (PLDR-3DCRT) plan and the rotation strength (PLDR-ARC) plan. Results: In the pancreatic cancer PLDR-IMRT program, the average dose of PTV in each individual field ranged from 17.6 cGy to 22.4 cGy with the maximum dose ranging from 22.9 cGy to 34.8 cGy. In the case of prostate cancer, the average dose of PTV in each individual field ranged from 18.8 cGy to 22.6 cGy with the maximum dose ranging from 24.0 cGy to 34.7 cGy. The dose of endangered organs in the IMRT plan is significantly smaller than that of three-dimensional conformal plan, which is close to the plan of rotation strengthening. CONCLUSIONS: In pulsed low-dose radiation therapy, IMRT programs have advantages over the commonly used 3DCRT programs through optimized design, reducing organ damage at the target dose level.