【摘 要】
：
为了寻求新颖的氨基噻唑类先导化合物,以含各种取代基的2-氨基噻唑在其氨基位置与拟除虫菊酯类农药的活性基团——菊酸采用亚结构对接的方法合成了35个N-(取代噻唑-2-基)-菊
【机 构】
：
浙江大学农业与生物技术学院农药与环境毒理研究所,
论文部分内容阅读
为了寻求新颖的氨基噻唑类先导化合物,以含各种取代基的2-氨基噻唑在其氨基位置与拟除虫菊酯类农药的活性基团——菊酸采用亚结构对接的方法合成了35个N-(取代噻唑-2-基)-菊酰胺类化合物,经1HNMR,ESI-MS和元素分析对化合物的结构进行了表征.初步生物活性测定表明,化合物3d,6a,6d,4a,4b,4c和4e在600mg/L下对小菜蛾具有100%的杀虫活性,化合物3d和7c在50mg/L下对多种常见病原菌具有显著的杀菌活性,全部化合物没有明显的除草活性.
In order to find novel aminothiazole lead compounds, 35 N (2-aminothiazoles) derivatives were synthesized by substituting 2-aminothiazoles with various substituents at their amino groups with subunits of chrysanthemic acid, the active group of pyrethroid pesticides - (substituted thiazol-2-yl) -chrysamides were synthesized and characterized by 1HNMR, ESI-MS and elemental analysis. The preliminary bioassay showed that compounds 3d, 6a, 6d, 4a, 4b, 4c And 4e had 100% insecticidal activity against Plutella xylostella at 600mg / L. Compounds 3d and 7c showed significant bactericidal activity against many common pathogens at 50mg / L, and all the compounds had no obvious herbicidal activity.
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