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引言:合霉素是氯霉素的一种消旋化合物,它是由等量的氯霉素左旋部分(左旋霉素)及右旋部分(右旋霉素)組成。在临床上应用于治疗伤寒、斑疹伤寒、痢疾、百日咳、淋病、布氏杆菌病、丹毒、化膿創伤、癰、癤及其他化膿性傳染等。其疗效一般認为并不低于氯霉素,但其成本却仅为后者的1/4,而且从等量原料制造合霉素要比氯霉素多产2—3倍,故近年来此药在临床上应用甚为广泛,然其毒性反应尚少报道。我院自1955年起开始使用合霉素治疗某些疾病,由于門診材料記录不全,故本文仅收集100例使用合霉素的住院病例(疾病名称見表1),对其毒性反应
INTRODUCTION Chlortetracycline is a racemic compound of chloramphenicol consisting of the equivalent amount of the levorotatory portion of levomycin (levomycin) and the dextrorotatory portion (dextromycin). In clinical application in the treatment of typhoid fever, typhus, dysentery, whooping cough, gonorrhea, brucellosis, erysipelas, suppurative trauma, 痈, 疖 and other suppurative infections. Its efficacy is generally considered not less than chloramphenicol, but its cost is only 1/4 of the latter, but also from the same amount of raw materials to produce chlortomycin synthase 2-3 times more productive, so in recent years The drug is widely used in clinical, but its toxicity is still rarely reported. Since 1955, our hospital began to use hypnotin to treat certain diseases. Since incomplete records of outpatient materials were collected, only 100 cases of inomycin-containing inpatients (names of diseases as shown in Table 1) were collected in this paper, and their toxicities