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目的:观察采用银翘解毒汤辅助治疗儿童水痘的临床疗效。方法:采用随机数字表法将河南省中医院及河南省传染病医院2013年1月~2015年1月收治的158例水痘患儿分为观察组和对照组各79例,两组患儿均给予阿昔洛韦片及西咪替丁片进行治疗,观察组患儿加用银翘解毒汤辅助治疗,两组患儿治疗时间均为1周,比较两组患儿临床疗效。结果:观察组患儿退热时间、止痒时间、基本结痂时间均显著短于对照组(P<0.05)。观察组患儿疱疹痊愈时间主要分布于第2~3天(40.51%),对照组主要分布于第6~7天(41.77%),观察组患儿的疱疹痊愈时间分布显著优于对照组(P<0.05)。治疗后第3、5天观察组患儿血清IL-8水平均显著低于对照组(P<0.05)。治疗7天后观察组患儿的痊愈率(65.82%)显著高于对照组(49.37%)(P<0.05),观察组的总有效率(98.73%)高于对照组(94.94%),但差异无统计学意义(P>0.05)。观察组治疗过程中的不良反应发生率(8.86%)显著低于对照组(20.25%)(P<0.05)。结论:银翘解毒汤辅助常规疗法治疗儿童水痘能缩短治疗时间、进一步提高疗效。
Objective: To observe the clinical efficacy of Yinqiao Jiedu Decoction in the treatment of chickenpox in children. Methods: A total of 158 cases of chickenpox in Henan Province Hospital of Traditional Chinese Medicine and Henan Infectious Disease Hospital from January 2013 to January 2015 were randomly divided into observation group (79 cases) and control group (79 cases) Given acyclovir tablets and cimetidine tablets for treatment, the observation group plus Yinqiao Jiedu Tang adjuvant therapy, two groups of children were treated for 1 week, the clinical efficacy of two groups were compared. Results: The antipyretic time, antipruritic time and basic scab time in the observation group were significantly shorter than those in the control group (P <0.05). The healing time of herpes in the observation group was mainly distributed on the 2nd to 3rd days (40.51%), while the control group mainly distributed on the 6th to 7th days (41.77%). The herpes healing time distribution in the observation group was significantly better than that of the control group P <0.05). The levels of serum IL-8 in the observation group were significantly lower than those in the control group on the 3rd and 5th days after treatment (P <0.05). The cure rate in the observation group was significantly higher than that in the control group (65.82%) after 7 days of treatment (49.37%, P <0.05). The total effective rate (98.73%) in the observation group was higher than that in the control group (94.94% No statistical significance (P> 0.05). The incidence of adverse reactions in the observation group (8.86%) was significantly lower than that in the control group (20.25%) (P <0.05). Conclusion: Yinqiao Jiedu Decoction assisted conventional treatment of children with chickenpox can shorten the treatment time and further improve the efficacy.