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高血压病人30例,正常血压对照30例,采用Laser Doppler血流计测定手指皮肤血流量,间接测定甲襞毛细血管压,并计算皮肤血流阻力,以袖带法测量肱动脉、桡动脉和指动脉血压,计算出平均血压和毛细血管前压降。结果显示:高血压组皮肤微循环中的血流阻力和毛细血管压升高(26.77±14.53对17.74±9.28mmHg/V,P<0.01;68.68±19.42对43.11±10.30mmHg,P<0.01),而皮肤血流改变无显著性差异(2.56±1.01对2.43±0.92,P>0.05);高血压组毛细血管压升高与其上游压降呈负相关关系(r=-0.78,P<0.01),提示皮肤毛细血管压和血流阻力是受其上游“阻力血管”所控制。用血管扩张剂治疗后的病人,血压明显下降而皮肤血流阻力仍处于升高状态。从而提示皮肤血流阻力的“结构成份”增加并借此作为评价“结构阻力”可逆性的客观指标。
30 cases of hypertensive patients and 30 cases of normal blood pressure control. The blood flow of finger skin was measured by Laser Doppler flowmeter, the capillary pressure of capillaries was measured indirectly and the skin blood flow resistance was calculated. The brachial artery, radial artery and Refers to arterial blood pressure, calculate the average blood pressure and pre-capillary pressure drop. The results showed that the blood flow resistance and capillary pressure in the skin microcirculation of hypertension group were significantly higher (26.77 ± 14.53 vs 17.74 ± 9.28mmHg / V, P <0.01; 68.68 ± 19.42 vs 43.11 ± 10.30mmHg, P <0.01) (2.56 ± 1.01 vs 2.43 ± 0.92, P> 0.05). There was a negative correlation between the capillary pressure and the pressure drop in the upper stream in hypertension group (r = -0.78, P <0.01), while there was no significant difference between the two groups Tip skin capillary pressure and blood flow resistance is controlled by its upstream “resistance blood vessels.” After treatment with vasodilator patients, blood pressure decreased significantly and skin resistance to blood flow is still elevated. Thereby suggesting an increase in “structural components” of the skin’s resistance to blood flow and as an objective measure of the reversibility of “structural resistance”.