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目的探究卡马西平联合叶酸治疗妊娠期癫痫效果及对母婴结局的影响。方法将2013年10月-2016年6月该院收治的82例妊娠期癫痫患者根据入院时间分为观察组和对照组,每组各41例。对照组服用卡马西平,观察组服用卡马西平加叶酸,观察并记录两组患者妊娠期癫痫发作程度、发作次数、胎儿妊娠结局及并发症发生情况。结果观察组孕妇妊娠期癫痫发作6例,发作率为14.63%;对照组孕妇妊娠期癫痫发作17例,发作率为41.47%,两组比较差异有统计学意义(P<0.05)。观察组孕妇出现妊娠高血压综合征、癫痫发作以及抑郁症等并发症概率显著低于对照组(P<0.05);两组孕妇流产、早产以及前置胎盘例数比较差异无统计学意义(P>0.05)。观察组新生儿畸形率为7.32%,对照组为29.27%,两组比较差异有统计学意义(P<0.05);两组出现死胎、胎儿宫内窘迫和低出生体重儿的概率比较差异无统计学意义(P>0.05)。结论卡马西平联合叶酸治疗妊娠期癫痫效果较好,癫痫发作情况得到有效控制,孕妇妊娠高血压综合征、围生期癫痫发作以及新生儿畸形、低出生体重儿等不良事件发生概率显著降低。
Objective To investigate the effect of carbamazepine combined with folic acid on the treatment of gestational epilepsy and its effect on maternal and infant outcomes. Methods From October 2013 to June 2016, 82 cases of pregnancy-induced epilepsy admitted to our hospital were divided into observation group and control group according to the time of admission. Each group had 41 cases. The control group took carbamazepine, and the observation group took carbamazepine plus folic acid. The degree of seizure during pregnancy, number of seizures, fetal pregnancy outcome and complications were observed and recorded in both groups. Results In the observation group, 6 pregnant women with seizures during pregnancy had a seizure rate of 14.63%. In the control group, 17 seizures occurred during pregnancy, with a seizure rate of 41.47%. The difference between the two groups was statistically significant (P <0.05). The probability of complications such as pregnancy-induced hypertension syndrome, seizure and depression in observation group was significantly lower than that in control group (P <0.05). There was no significant difference in the number of miscarriage, premature labor and placenta previa > 0.05). The incidence of neonatal deformity was 7.32% in the observation group and 29.27% in the control group, with significant difference between the two groups (P <0.05). There was no statistical difference in the probability of stillbirth, fetal distress and low birth weight children Significance (P> 0.05). Conclusions Carbamazepine combined with folic acid is effective in treating gestational epilepsy and the control of seizures is effectively controlled. The incidence of pregnancy-induced hypertension syndrome, perinatal seizures, neonatal malformations and low birth weight children are significantly reduced.