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目的分析研究反复呼吸道感染(RRI)儿童联合匹多莫德和维生素D治疗的疗效和对机体免疫功能的影响。方法 100例RRI儿童为研究对象,采用随机法分为对照组和观察组,各50例。对照组患儿采用常规治疗,观察组患儿在对照组基础上加用匹多莫德和维生素D治疗,随访6个月。对比两组临床疗效、临床症状消退时间、T细胞亚群和免疫球蛋白的变化,随访期间统计复发次数。结果观察组患儿总有效率(92%)显著高于对照组(80%),差异有统计学意义(P<0.05)。观察组患儿随访期间复发次数为(1.45±0.41)次,对照组患儿为(6.05±1.08)次,观察组患儿随访期间复发次数明显少于对照组(P<0.05)。观察组发热消退时间、扁桃体肿大消退时间、肺部啰音消退时间、咳嗽缓解时间均短于对照组,差异具有统计学意义(P<0.05);观察组治疗后T细胞亚群(CD3+、CD4+、CD8+)、免疫球蛋白A(Ig A)、免疫球蛋白G(Ig G)、免疫球蛋白M(Ig M)均高于对照组,差异具有统计学意义(P<0.05);对照组治疗前后T细胞亚群、免疫球蛋白比较差异无统计学意义(P>0.05)。结论 RRI儿童给予匹多莫德和维生素D联合治疗具有较好的疗效,可有效缓解临床症状,降低疾病的复发次数,同时还显著增强患儿的细胞免疫和体液免疫功能。
Objective To study the effects of combined pidotimod and vitamin D therapy on immune function in children with recurrent respiratory infections (RRI). Methods 100 cases of RRI children as the research object, randomized into control group and observation group, 50 cases each. Children in the control group were treated with conventional therapy. The children in the observation group were treated with pidotimod and vitamin D on the basis of the control group, and were followed up for 6 months. The clinical curative effect, clinical symptom subsidence time, changes of T cell subsets and immunoglobulin in the two groups were compared, and the number of recurrence was counted during follow-up. Results The total effective rate (92%) in observation group was significantly higher than that in control group (80%), the difference was statistically significant (P <0.05). The number of recurrence in observation group was (1.45 ± 0.41) and in control group (6.05 ± 1.08), and the number of recurrence in observation group was significantly less than that in control group (P <0.05). The observation group subsided fever, tonsil swelling and remission time, pulmonary rales and remission time, cough relief time shorter than the control group, the difference was statistically significant (P <0.05); the observation group after treatment T cell subsets (CD3 + CD4 +, CD8 +), Ig A, Ig G and Ig M were significantly higher in the control group than those in the control group (P <0.05) Before and after treatment T cell subsets, immunoglobulins showed no significant difference (P> 0.05). Conclusion RRI children with podimod and vitamin D combination therapy has good curative effect, which can effectively relieve clinical symptoms, reduce the number of disease relapse, but also significantly enhance children’s cellular and humoral immune function.