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目的:观察益气养阴、清热活血中药联合西药治疗糖尿病临床疗效,探讨其作用机理。方法:将80例患者随机分为2组,西药组40例,中西医结合组40例,西药组给予西医常规治疗,中西医结合组在西药组基础上给予益气养阴、清热活血方。观察时间为8周,主要观察指标:临床症状,体质量指数(body mass index,BMI)、空腹血糖(fasting blood glucose,FBG)、餐后2小时血糖(2 h Plasma Glucose,2h PG)、糖化血红蛋白(glycosylated hemoglobin,Hb A1c)、空腹胰岛素(fasting insulin,FIns)、胰岛素抵抗指数(Insulin resistance index,HOMA-IR)、肿瘤坏死因子(tumor necrosis factor-α,TNF-α)、总胆固醇(total cholesterol,TC)、三酰甘油(triglyeride,TG)、高密度脂蛋白(high density lipoprotein,HDL-C)、低密度脂蛋白(low density lipoprotein,LDL-C)。结果:中西医结合组干预后临床症状、BMI、FBG、2h PG、Hb A1c、FIns、HOMA-IR、TNF-α、TC、TG、HDL-C、LDL-C均有明显改善(P<0.05)。中西医结合组有效率80.00%,西药组有效率57.5%,两组有效率比较,差异有统计学意义(P<0.05)。结论:益气养阴、清热活血中药联合西药能显著改善糖尿病患者的临床症状、BMI、FBG、2h PG、Hb A1c、FIns、HOMA-IR、TNF-α、TC、TG、HDLC、LDL-C,具有良好的安全性。
Objective: To observe the clinical effect of qi and nourishing yin, clearing away heat and promoting blood flow traditional Chinese medicine combined with western medicine in the treatment of diabetes mellitus, and to explore its mechanism. Methods: Eighty patients were randomly divided into two groups: 40 in western medicine group and 40 in traditional Chinese medicine combined with western medicine group. The western medicine group was given routine western medicine treatment. The combination of traditional Chinese and western medicine group was given Yiqi Yangyin and Qingrehuoxue prescription on the basis of western medicine group. The observation time was 8 weeks and the main observation indexes were clinical symptoms, body mass index (BMI), fasting blood glucose (FBG), 2h plasma glucose (2h PG) Fasting insulin (FIns), Insulin resistance index (HOMA-IR), tumor necrosis factor-α (TNF-α), total cholesterol cholesterol, TC), triglyeride (TG), high density lipoprotein (HDL-C) and low density lipoprotein (LDL-C). Results: The clinical symptoms, BMI, FBG, 2h PG, Hb A1c, FIns, HOMA-IR, TNF-α, TC, TG, HDL-C and LDL-C in the combination group were significantly improved after intervention ). Integrative Medicine Group 80.00% effective rate of 57.5% in Western medicine group, the two groups were compared, the difference was statistically significant (P <0.05). Conclusion: The clinical symptoms, BMI, FBG, 2h PG, Hb A1c, FIns, HOMA-IR, TNF-α, TC, TG, HDLC and LDL-C were significantly improved in the patients with diabetes mellitus , With good safety.