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采用放射免疫法检测 2 5例肝硬化无腹水患者、2 6例肝硬化有腹水患者、12例肝肾综合征患者及 3 0例正常人血浆内皮素 ( ET)含量。结果 ,无腹水组血浆 ET浓度与正常人无显著差异 ;有腹水组血浆 ET为 64 .9± 11.6ng/L与正常人及无腹水组有显著差异 ( P<0 .0 1) ;肝肾综合征组血浆 ET为 10 8.1± 15 .3 ng/L与其它 3组均有显著差异 ( P<0 .0 1)。肝肾综合症患者血浆 ET浓度显著升高 ,提示 ET在该病发病机理中起一定作用
Twenty-five patients with liver cirrhosis without ascites, 26 patients with cirrhosis with ascites, 12 patients with hepatorenal syndrome and 30 normal subjects were detected by radioimmunoassay. As a result, there was no significant difference in plasma ET concentration between ascites group and normal subjects. The level of plasma ET in ascites group was significantly higher than that in normal group and non-ascitic group (64.9 ± 11.6ng / L, P <0.01) Syndrome group plasma ET was 10 8.1 ± 15 .3 ng / L and the other three groups were significantly different (P <0.01). Plasma ET levels in patients with hepatorenal syndrome are significantly elevated, suggesting that ET may play a role in the pathogenesis of the disease