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目的探讨女性卵巢癌发生的相关危险因素,为卵巢癌的防治提供依据。方法选取2010年5月~2014年6月在该院就诊并确诊的128例卵巢癌妇女作为病例组,另选取同期在该院就诊的128例非恶性肿瘤疾病妇女作为对照组。采用自制的统一调查问卷对两组妇女一般资料、婚育情况、既往疾病史、生活史等情况进行调查,并采用单因素和多因素方法分析卵巢癌发生的相关危险因素。结果病例组痛经发生率、妊娠≥2次发生率、自然流产≥1次发生率、人工流产≥1次发生率、月经期<4 d率均显著高于对照组,差异均有统计学意义(P<0.05)。Logistic回归分析结果显示,自然流产≥1次(OR=2.057)、人工流产≥1次(OR=2.014)及月经期<4 d(OR=2.549)是并发卵巢癌的危险因素。结论积极治疗月经期紊乱、减少人工流产、足月妊娠可以降低卵巢癌的发生率。
Objective To investigate the risk factors associated with ovarian cancer in women and provide evidence for the prevention and treatment of ovarian cancer. Methods A total of 128 ovarian cancer patients diagnosed in our hospital from May 2010 to June 2014 were selected as the case group. Another 128 non-malignant tumor patients were selected as the control group during the same period. The self-made questionnaire was used to investigate the general information, marriage and childbearing conditions, past disease history and life history of two groups of women and to analyze the related risk factors of ovarian cancer by single factor and multi-factor methods. Results The incidence of dysmenorrhea, incidence of pregnancy ≥ 2, incidence of spontaneous abortion ≥ 1, incidence of induced abortion ≥ 1, menstruation <4 d were significantly higher than those of the control group (P < P <0.05). Logistic regression analysis showed that spontaneous abortion ≥1 (OR = 2.057), induced abortion ≥1 (OR = 2.014) and menstrual period <4 d (OR = 2.549) were risk factors for concurrent ovarian cancer. Conclusion Active treatment of menstrual disorders, reduce induced abortion, full-term pregnancy can reduce the incidence of ovarian cancer.