论文部分内容阅读
许多因素如营养失平衡、化学毒物与药物、空气污染、辐射、剧烈运动、创伤等均能在细胞内环境启动或增加氧化应激反应。自由基所致细胞膜多不饱和脂肪酸脂质过氧化是氧化应激引起的最常见的损伤。脂质过氧化进一步发展可造成低密度脂蛋白氧化修饰,后者是动脉硬化的重要原因。氧化应激可导致20多种 DNA 损伤,其中许多是突变,这些损伤的积累是癌症和其它退行性疾病发生的原因。维生素 C、E 或β-胡萝卜素可通过清除各种自由基如 OH~·、O_2~-、~1O_2及 L~·、LO~·等抑制自由基启动脂质过氧化或阻断脂质过氧化链式反应,保护机体免受氧化损伤。
Many factors such as nutritional imbalance, chemical poisons and drugs, air pollution, radiation, strenuous exercise, trauma and so on can start in the intracellular environment or increase the oxidative stress response. Free radical induced cell membrane Polyunsaturated fatty acids Lipid peroxidation is the most common injury caused by oxidative stress. Further development of lipid peroxidation can lead to oxidative modification of LDL, which is an important cause of atherosclerosis. Oxidative stress can lead to more than 20 DNA damage, many of which are mutations that contribute to the development of cancer and other degenerative diseases. Vitamin C, E or β-carotene can inhibit free radicals such as OH ~ ·, O_2 ~ -, ~ 1O_2 and L ~ ·, LO ~ · inhibition of lipid peroxidation or lipid peroxidation Oxidative chain reaction to protect the body from oxidative damage.