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目的:探讨甲状腺激素在绝经后女性动脉粥样硬化中的作用。方法:在167名自然绝经女性患者中,以彩色多普勒超声诊断为颈动脉粥样硬化、斑块形成者127例为观察组,以40例健康体检无动脉粥样硬化者为对照组,比较两组的年龄、体重指数(BM I)、雌二醇(E2)和甲状腺激素FT3、FT4、hTSH水平。结果:两组的年龄、BM I和E2水平差异无统计学意义。观察组FT3、FT4水平明显低于对照组(P<0.05),hTSH水平显著高于对照组(P<0.001),其中hTSH≥10μIU/ml者占71.4%。结论:绝经后女性动脉粥样硬化的发生与甲状腺功能密切相关。
Objective: To investigate the role of thyroid hormone in atherosclerosis in postmenopausal women. Methods: A total of 167 patients with natural menopause were diagnosed as carotid atherosclerosis by color Doppler sonography. The plaque formation was observed in 127 cases and the control group was 40 cases without any atherosclerosis. Age, body mass index (BM I), estradiol (E2) and thyroid hormones FT3, FT4 and hTSH were compared between the two groups. Results: There was no significant difference in age, BM I and E2 between the two groups. The levels of FT3 and FT4 in the observation group were significantly lower than those in the control group (P <0.05), and the levels of hTSH in the observation group were significantly higher than those in the control group (P <0.001). The percentage of patients with hTSH≥10μIU / ml was 71.4%. Conclusion: The incidence of atherosclerosis in postmenopausal women is closely related to thyroid function.