目的:了解昌平地区出生缺陷(Birth Defects BDs)的发生率,掌握严重和高发出生缺陷的动态变化趋势。方法:按全国出生缺陷监测网要求,将1999~2008年分为前、后5年,对孕28周~产后7天的围产儿出生缺陷发生情况进行对比;分析10年间妊娠中期胎儿畸形的引产情况。结果:10年间监测地区围产儿共45656例,出生缺陷儿471例,出生缺陷发生率为10.32‰;围产儿死亡275例,出生缺陷儿死亡72例,占围产儿死亡的26.18%。结论:积极开展出生缺陷干预工程,推广神经管畸形(NTDs)在孕早、孕中期的筛查技术和孕早期优生四项(ToRCT)的检查工作,采取管理、医疗、社会及法律等综合措施,能有效降低出生缺陷发生率。 Objective: To understand the incidence of birth defects (Birth Defects BDs) in Changping area and to master the dynamic trends of severe and high birth defects. Methods: According to the requirements of National Birth Defects Monitoring Network, the incidence of birth defects in perinatal children between 28 weeks after birth and 7 days after birth was compared between 1999 and 2008 before and after 5 years. The incidence of fetal malformation in mid-second trimester was analyzed Happening. Results: During the 10 years, there were 45 656 perinatal children and 471 neonates with birth defects. The incidence of birth defects was 10.32 ‰. There were 275 perinatal deaths, 72 birth defects and 26.18% perinatal deaths. CONCLUSION: We actively carry out the birth defect intervention project to promote the screening of neural tube defects (NTDs) during the first trimester and the second trimester as well as the examination of ToRCT during the first trimester, and take comprehensive management, medical, social and legal measures , Can effectively reduce the incidence of birth defects.