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目的比较硫普罗宁与甘草酸二胺治疗慢性病毒性乙型肝炎(CHB)的临床疗效。方法选取攀枝花市第四人民医院2014年3月—2016年3月收治的CHB患者126例,根据用药方案的不同分为对照组(n=62)和观察组(n=64)。患者入院后均给予常规对症治疗,对照组患者给予甘草酸二铵胶囊治疗,观察组患者给予硫普罗宁肠溶胶囊治疗,两组患者均持续治疗6个月。比较两组患者治疗后大三阳、小三阳、双阳、抗-HBs阳性发生率及恢复期率、临床疗效、不良反应发生情况。结果治疗后,观察组患者大三阳、小三阳发生率低于对照组,恢复期、抗-HBs阳性发生率高于对照组(P<0.05),两组患者双阳发生率比较,差异无统计学意义(P>0.05)。观察组患者临床疗效优于对照组(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论采用硫普罗宁治疗CHB的临床疗效优于甘草酸二铵,可更有效改善患者肝功能,且安全性好。
Objective To compare the clinical efficacy of tiopronin and glycyrrhizic acid in the treatment of chronic viral hepatitis B (CHB). Methods A total of 126 CHB patients admitted to the Fourth People ’s Hospital of Panzhihua City from March 2014 to March 2016 were divided into control group (n = 62) and observation group (n = 64) according to different dosage regimen. All patients were given conventional symptomatic treatment after admission. Patients in the control group were treated with diammonium glycyrrhizinate capsules. Patients in the observation group were given tiopronin enteric-coated capsules. Both groups were treated for 6 months. The positive and negative rates of Dansan Yang, Xiaosanyang, Shuangyang, and anti-HBs were compared between the two groups after treatment. The clinical efficacy and incidence of adverse reactions were compared between the two groups. Results After treatment, the incidences of Dasan yang and Xiaosanyang in the observation group were lower than those in the control group. The positive rate of anti-HBs in the recovery group was higher than that in the control group (P <0.05). There was no statistical difference between the two groups Significance (P> 0.05). The clinical efficacy of the observation group was better than that of the control group (P <0.05). Two groups of patients with adverse reactions, the difference was not statistically significant (P> 0.05). Conclusion The clinical efficacy of tiopronin in the treatment of CHB is better than that of diammonium glycyrrhizinate, which can improve the liver function more effectively and is safe.