本文报告1例长期膜性肾小球肾炎患者,口服速尿和双氢克尿塞诱发间质性肾炎。患者男,60岁,16年前因全身浮肿和蛋白尿(4+)住院。口服类固醇1年余,浮肿消失,蛋白尿减少。以后除偶尔踝部浮肿和中度蛋白尿外,一直无症状。近一年出现高血压160/105毫米汞柱),凹陷性浮肿和蛋白尿(4+),给用利血平,肼苯达嗪、双氢克尿塞(12.5～62.5毫克/天,共14个月)、速尿(40毫克/天、共9个月)及短期的心得安治疗。以后肌酐从27 This article reports 1 case of long-term membranous glomerulonephritis patients, oral furosemide and hydrochlorothiazide-induced interstitial nephritis. The patient, male, 60 years old, was hospitalized 16 years ago for systemic edema and proteinuria (4+). Oral steroids more than 1 year, edema disappeared, proteinuria decreased. In addition to occasional ankle swelling and moderate proteinuria, has been asymptomatic. Hypertension 160/105 mmHg in the recent year), pitting edema and proteinuria (4+), reserpine, hydralazine and hydrochlorothiazide (12.5 to 62.5 mg / day for 14 months) , Furosemide (40 mg / day, a total of 9 months) and short-term treatment of peace. After creatinine from 27