【摘 要】
：
The title compound 2-(2-chloro-4-nitrophenyl)-4-(4-chlorophenyl)-3a,4- diethoxy- 2,3,3a, 4-tetrahydrochromeno[3,4-d][1,2,3]diazaphosphole 2 (C29H30Cl2N3O7P, Mr
【机 构】
：
ZJU-ENS Joint Laboratory of Medicinal Chemistry
论文部分内容阅读
The title compound 2-(2-chloro-4-nitrophenyl)-4-(4-chlorophenyl)-3a,4- diethoxy- 2,3,3a, 4-tetrahydrochromeno[3,4-d][1,2,3]diazaphosphole 2 (C29H30Cl2N3O7P, Mr = 633.44) was synthesized and its structure was characterized by IR, MS, 1H NMR, 13C NMR, 31P NMR, elemental analysis and single-crystal X-ray diffraction. It crystallizes in triclinic, space group P, a = 9.1549(3), b = 10.7168(4), c = 17.6272(6) ?, α = 102.9363(12), β = 90.2713(9), γ = 117.4265(10)°, V = 1484.41(9) ?3, Z = 2, μ(MoKα) = 0.323, F(000) = 658, Z = 2, Dc = 1.417 g/cm3, the final R = 0.0687 and wR = 0.2066 for 4943 observed reflections (I > 2σ(I)). X-ray analysis reveals that the diazaphospholine ring is almost planar and the two ethoxy groups bonded on the 3a- and 4-positions are in trans configurations. Its antiproliferative activity was also tested in vitro against four human tumor cell lines.
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