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胎儿先天性心脏病的病因尚未完全明确,这在一定程度上阻碍了先天性心脏病的预防。近年先天性心脏病非遗传性病因的研究取得很大进展,目前认为与妊娠期叶酸缺乏、妊娠期疾病(糖尿病、苯丙酮尿症、高同型半胱氨酸血症、肥胖)、妊娠期感染(风疹病毒、微小病毒B19、尿路感染)、妊娠期用药(抗生素、抗高血压药物、非甾体类抗炎药等)、环境因素(太阳活动、宇宙射线、化学剂、空气污染、水加氯处理后副产品等)、不良生活行为习惯(吸烟、饮酒、吸毒)等方面相关,从以上几个方面对先天性心脏病非遗传性病因进行综述,旨在能对先天性心脏病的预防起到一定启示作用。
The etiology of fetal congenital heart disease is not yet completely clear, which to some extent hindered the prevention of congenital heart disease. In recent years, great progress has been made in the study of the non-hereditary cause of congenital heart disease. At present, it is thought to be associated with folic acid deficiency during pregnancy, gestational diseases (diabetes, phenylketonuria, hyperhomocysteinemia, obesity), gestational infections (Rubella virus, parvovirus B19, urinary tract infections), medication during pregnancy (antibiotics, antihypertensives, NSAIDs, etc.), environmental factors (solar activity, cosmic rays, chemicals, air pollution, water Chlorinated by-products, etc.), bad habits and habits (smoking, drinking, drug abuse) and so on, from the above aspects of congenital heart disease non-hereditary causes are reviewed in order to prevent congenital heart disease Play a role of inspiration.