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目的探讨幽门螺杆菌(HP)感染对特发性血小板减少性紫癜(ITP)患者CD4~+CD25~+T调节细胞的影响,进一步揭示ITP的发病机制,为临床诊断、治疗与预防提供重要的理论依据。方法 2013年1月至2014年12月门诊及住院收治的ITP患者33例纳入ITP组,HP阴性13例,HP阳性30例。另选取健康体检者40例作为对照组,其中HP阴性23例,HP阳性17例;均测定血清CD4~+CD25~+T调节细胞的浓度。结果 ITP组HP阳性率明显高于对照组,差异有统计学意义。对照组HP阴性者与对照组HP阳性者CD4~+CD25~+T调节细胞的浓度比较,差异有统计学意义(P<0.05)。对照组HP阴性者、阳性者分别与ITP组HP阴性者、阳性者比较,差异有统计学意义(P<0.05)。ITP组HP阴性者与HP阳性者比较,差异无统计学意义(P>0.05)。结论 HP感染与ITP的发病有一定关系,健康人群HP感染可增加CD4~+CD25~+T调节细胞的浓度;与健康人相比,ITP患者CD4~+CD25~+T调节细胞的浓度降低;而HP感染ITP对CD4~+CD25~+T调节细胞没有影响。
Objective To investigate the effect of Helicobacter pylori (HP) infection on CD4 ~ + CD25 ~ + T regulatory cells in patients with idiopathic thrombocytopenic purpura (ITP), and to further reveal the pathogenesis of ITP and provide important information for clinical diagnosis, treatment and prevention Theoretical basis. Methods From January 2013 to December 2014, 33 outpatients and hospitalized patients with ITP were enrolled in the ITP group. Thirteen patients were negative for HP, 13 were positive for HP, and 30 were positive for HP. Another 40 healthy subjects were selected as the control group, of which 23 were negative for HP and 17 were positive for HP. Serum concentrations of CD4 ~ + CD25 ~ + T regulatory cells were measured. Results The positive rate of HP in ITP group was significantly higher than that in control group, the difference was statistically significant. The difference of CD4 ~ + CD25 ~ + T regulatory cells in HP-positive and control-positive patients in control group was statistically significant (P <0.05). In the control group, there was a significant difference between the HP positive and the negative ones in the ITP group (P <0.05). There was no significant difference between ITP group and HP positive group (P> 0.05). Conclusion HP infection is related to the pathogenesis of ITP. HP infection of healthy people can increase the concentration of CD4 ~ + CD25 ~ + T regulatory cells. Compared with healthy controls, the concentration of CD4 ~ + CD25 ~ + T regulatory cells in ITP patients decreased. HP infected ITP had no effect on CD4 ~ + CD25 ~ + T regulatory cells.