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目的探讨新疆维、汉、哈族成年人群代谢综合征(MS)与颈动脉内中膜厚度(IMT)的关联性。方法采用整群抽样的流行病学调查的方法进行抽样调查15061人,实际共完成14618人。根据MS的诊断标准分为MS患病组(MS组,3356例)与非患病组(非MS组,11262例)。对所有患者均记录体重、身高、吸烟史、收缩压、舒张压,并测定其血糖、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C),计算其体重指数(BMI)等;同时完成颈动脉IMT等动脉硬化指标的测量,应用SPSS11.0统计软件分析不同民族MS患病率,同时分析MS与IMT的关联性。结果对于受检人群总体,MS组IMT值显著高于非MS组[(0.077±0.030)cmvs.(0.072±0.030)cm,t=-9.239,P<0.001]。维族、汉族、哈族MS组的IMT值均显著高于非MS组(t=-5.80,P<0.001;t=-6.877,P<0.001;t=-2.805,P=0.005)。经校正年龄、性别等影响因素后,总体人群及维族、汉族的MS组与非MS组IMT仍有显著差异(P均<0.05),哈族两组间IMT无统计学差异(P=0.371)。结论对于新疆维、汉族人群,MS可以增加动脉粥样硬化发生的风险,对哈族人群的IMT无明显影响,对MS患者及早进行颈动脉的超声检查,将有助于心血管病事件的一级预防。
Objective To investigate the association between metabolic syndrome (MS) and carotid intima-media thickness (IMT) in adult population of Victoria, Han and Ha nationality in Xinjiang. Methods A total of 15061 people were surveyed by means of cluster sampling epidemiological survey, with a total of 14618 people actually completed. According to the diagnostic criteria of MS, the patients were divided into MS diseased group (MS group, 3356 cases) and non-diseased group (non-MS group, 11262 cases). Body weight, height, smoking history, systolic blood pressure and diastolic blood pressure were recorded in all patients. Blood glucose, total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) (LDL-C), calculate the body mass index (BMI); at the same time to complete the measurement of carotid artery IMT and other indicators of atherosclerosis, SPSS11.0 statistical software to analyze the prevalence of MS in different ethnic groups, while MS and IMT analysis of the association Sex. Results The overall IMT value of MS group was significantly higher than that of non-MS group [(0.077 ± 0.030) cm vs (0.072 ± 0.030) cm, t = -9.239, P <0.001] The IMT values in Uygur, Han and Kazakh MS groups were significantly higher than those in non-MS groups (t = -5.80, P <0.001; t = -6.877, P <0.001; t = -2.805, P = 0.005). After adjusting for age and sex, there was still significant difference in IMT between MS group and non-MS group in general population and Uygur and Han nationalities (all P <0.05), but there was no significant difference in IMT between two groups (P = 0.371) . Conclusion MS and MS can increase the risk of atherosclerosis in Xinjiang Uygur and Han nationality population, but have no significant effect on the IMT of Ha ethnic group. Early ultrasound examination of carotid arteries in MS patients will contribute to the development of cardiovascular disease Prevention.