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目的探讨影响肝硬化并发肝性脑病(HE)患者预后的危险因素。方法回顾性分析肝硬化并发HE患者70例,分为存活组49例,死亡组21例。统计两组HE患者的年龄、性别、肝功能、PTA、血清钠、血BUN、血氨、肝性脑病的分期及肝功能Child-pugh分级情况等。结果分析发现年龄、凝血酶原活动度、血清总胆红素、血清白蛋白、血清钠、血清尿素氮、肝性脑病的分期及肝功能Child-pugh分级等与肝硬化并发HE患者预后有关(P<0.05),而血氨值的高低与其预后不相关。结论对于肝硬化并发HE患者,年龄越大、感染越重、合并肝硬化其他并发症、肝脏储备功能越差者,预后越不良。早期判断、预防、治疗这些危险因素,对改善预后有重要意义。
Objective To investigate the risk factors affecting the prognosis of cirrhotic patients with hepatic encephalopathy (HE). Methods Retrospective analysis of 70 patients with liver cirrhosis complicated with HE, divided into survival group of 49 cases, 21 cases of death. The age, gender, liver function, PTA, serum sodium, blood BUN, blood ammonia, hepatic encephalopathy staging and liver function Child-pugh grading were calculated in two groups of HE patients. Results Analysis showed that age, prothrombin activity, serum total bilirubin, serum albumin, serum sodium, serum urea nitrogen, hepatic encephalopathy staging and liver function Child-pugh grading and liver cirrhosis complicated with HE prognosis P <0.05), while the level of serum ammonia is not associated with its prognosis. Conclusions For patients with liver cirrhosis complicated with HE, the older the patients, the more severe the infection, and the complications associated with liver cirrhosis. The worse the liver reserve function, the worse the prognosis. Early judgment, prevention, treatment of these risk factors, to improve the prognosis of great significance.