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目的:对我院2008年1月至2013年1月NICU中新生儿败血症的病原菌进行分析并探讨临床治疗败血症患儿的早期最佳药物选择。方法:分析我院NICU 75例新生儿败血症患儿临床资料、血培养结果,根据细菌培养阳性结果及药敏情况进行药物选择。结果:75例血培养阳性新生儿败血症共获得92株细菌,其中革兰阳性球菌58株(63.04%),革兰阴性杆菌31株(33.70%),另有3株(3.26%)为真菌。本次检出的病原菌对青霉素和红霉素等常用抗菌药物耐药性很高,总耐药率高达90%。革兰阴性杆菌对氨苄西林、头孢唑林耐药率较高在85%左右,对哌拉西林、头孢他啶、头孢曲松的耐药率偏高,总耐药率在25%~50%。结论:我院NICU中新生儿败血症病原菌以革兰阳性球菌为主,且耐药率较高,要警惕真菌感染可能。
Objective: To analyze the pathogens of neonatal sepsis in NICU from January 2008 to January 2013 in our hospital and to explore the best early drug selection in clinical treatment of sepsis in children. Methods: The clinical data and blood culture results of 75 neonates with sepsis in NICU of our hospital were analyzed. Drug selection was made according to positive results of bacterial culture and drug susceptibility. Results: A total of 92 strains of bacteria were found in 75 blood-positive neonates with septicemia, of which 58 (63.04%) were Gram-positive cocci, 31 (33.70%) were Gram-negative bacilli and the other 3 (3.26%) were fungi. The detection of pathogens on penicillin and erythromycin and other commonly used antimicrobial resistance is high, the total resistance rate as high as 90%. Gram-negative bacilli showed high resistance rates to ampicillin and cefazolin at around 85%. The resistance rate to piperacillin, ceftazidime and ceftriaxone was high, with a total resistance rate of 25% -50%. Conclusion: Neonatal sepsis pathogens in NICU of our hospital are mainly Gram-positive cocci, and the rate of drug resistance is relatively high. Be wary of possible fungal infection.