论文部分内容阅读
[目的]观察益气化瘀胶囊联合拜阿司匹林与阿托伐他汀钙治疗气虚血瘀动脉粥样硬化疗效。[方法]使用随机平行对照方法,将78例住院及门诊患者按就诊先后顺序方法简单随机分为两组。对照组38例拜阿司匹林,100mg/d;阿托伐他汀钙,20mg/d。治疗组40例益气化瘀胶囊(黄芪60g,太子参30g,川芎15g,地龙、赤芍各10g,鸡血藤30g,每粒含生药2.8g),2粒/次,3/d;拜阿司匹林与阿托伐他汀钙治疗同对照组。连续治疗8周为1疗程。观测临床症状、血脂(TC、TG、H-DLC、LDL-C)、颈动脉IMT、hs-CRP、IL-6、不良反应。连续治疗2疗程,判定疗效。[结果]治疗组显效17例,有效18例,无效5例,总有效率87.50%;对照组显效10例,有效14例,无效14例,总有效率63.16%;治疗组疗效优于对照组(P<0.05)。血脂(TC、TG、H-DLC、LDL-C)、颈动脉IMT、hs-CRP、IL-6两组均有改善(P<0.05,P<0.01),治疗组改善优于对照组(P<0.05,P<0.01)。[结论]益气化瘀胶囊联合拜阿司匹林与阿托伐他汀钙治疗气虚血瘀动脉粥样硬化,疗效满意,无严重不良反应,值得推广。
[Objective] To observe the curative effect of Yiqi Huayu capsule combined with aspirin and atorvastatin calcium on atherosclerosis of qi deficiency and blood stasis. [Methods] Using randomized parallel control method, 78 cases of inpatients and outpatients were randomly divided into two groups according to the order of treatment. 38 cases of aspirin control group, 100mg / d; atorvastatin calcium, 20mg / d. In the treatment group, 40 cases were treated with Yiqi Huayu Capsule (Astragalus 60g, Pseudostellaria heterophylla 30g, Rhizoma Chuanxiong 15g, earthworm, Radix Paeoniae Rubra 10g, Millettia 30g, 2.8g each containing crude drug), 2 capsules / time, Aspirin and atorvastatin calcium treatment with the control group. Continuous treatment for 8 weeks for a course of treatment. Clinical symptoms, blood lipids (TC, TG, H-DLC, LDL-C), carotid IMT, hs-CRP, IL-6 and adverse reactions were observed. Continuous treatment of 2 courses to determine the efficacy. [Results] In the treatment group, 17 cases were markedly effective, 18 cases were effective, 5 cases were ineffective, and the total effective rate was 87.50%. In the control group, 10 cases were markedly effective, 14 cases were effective and 14 cases were ineffective. The total effective rate was 63.16% (P <0.05). The levels of serum lipids (TC, TG, H-DLC, LDL-C), carotid IMT, hs-CRP and IL-6 in both groups were improved (P < <0.05, P <0.01). [Conclusion] Yiqi Huayu capsule combined with aspirin and atorvastatin calcium can treat atherosclerosis of qi deficiency and blood stasis with satisfactory curative effect and no serious adverse reactions, which deserves promotion.