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本课题通过免疫学、皮肤微血管电子显微镜观察和临床抗过敏疗法等研究结果证明,Ⅰ型变态反应参与流行性出血热早期发病过程。免疫学研究结果表明,病人各期血清中总IgE 含量均高于正常人3～4倍(P<0.001),且其升高趋势与病程变化或病情的严重程度密切相关;病人血清中IgE 的动力学变化与其所介导的肥大细胞脱颗粒阳性率、血清中组胺含量呈正相关,与血浆中cAMP 水平呈负相关。应用放射免疫变应原吸附试验(PRSAT)和间
The subject of immunology, skin microvascular electron microscopy and clinical anti-allergy therapy and other studies have shown that type Ⅰ allergic disease involved in the early onset of epidemic hemorrhagic fever. The results of immunological studies showed that the total IgE levels in serum of all patients were 3 to 4 times higher than those in normal people (P <0.001), and the increasing tendency was closely related to the course of disease or the severity of the disease. The serum IgE The change of kinetics was positively correlated with the degranulation rate of mast cells and histamine in serum, and negatively correlated with the level of cAMP in plasma. Application of radioimmunoassay test (PRSAT) and between