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目的探究纳洛酮在中重度酒精中毒治疗中的应用价值。方法 80例中重度急性酒精中毒患者,随机分为研究组及对照组,各40例。对照组患者给予常规治疗,研究组患者在对照组基础上加用盐酸纳洛酮治疗,比较两组患者苏醒时间、症状消失时间及治疗效果。结果治疗后,研究组患者苏醒时间及症状消失时间分别为(15.17±5.13)、(50.83±10.21)min,均短于对照组的(40.23±13.37)、(100.24±15.17)min,差异有统计学意义(P<0.05)。研究组患者治疗1 h后总有效率为92.50%,高于对照组的70.00%,差异有统计学意义(P<0.05)。结论对中重度酒精中毒患者给予纳洛酮治疗,疗效显著、安全可靠,值得临床推广。
Objective To investigate the application of naloxone in the treatment of moderate-severe alcoholism. Methods Eighty patients with moderate to severe acute alcoholism were randomly divided into study group and control group, 40 cases in each group. Patients in the control group were given routine treatment. Patients in the study group were treated with naloxone hydrochloride on the basis of the control group. The recovery time, the disappearance of symptoms and the therapeutic effect were compared between the two groups. Results After treatment, the recovery time and symptom disappearance time in study group were (15.17 ± 5.13) and (50.83 ± 10.21) min, respectively, which were shorter than those in control group (40.23 ± 13.37) and (100.24 ± 15.17) min, respectively Significance (P <0.05). The total effective rate of study group 1 h after treatment was 92.50%, which was higher than 70.00% of the control group, the difference was statistically significant (P <0.05). Conclusion Naloxone treatment is given to patients with moderate to severe alcoholism, which has significant curative effect, safe and reliable, and worthy of clinical promotion.