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目的分析甲状腺机能亢进症合并戊型肝炎的临床特点。方法将甲亢合并戊型肝炎患者 2 6例作为观察组 ,随机抽出同期住院的 30例戊型病毒性肝炎患者作为对照组 ,患者入院后采取静脉血 ,测定肝功 ,观察临床症状 ,体征 ,肝损害实验室指标的变化和转归。结果从临床表现上 ,观察组有乏力、厌食、恶心、腹胀等明显消化道症状 9例 ,较对照组明显。有皮肤瘙痒及灰白便者 1 3例 ,高黄疸者(血清总胆红素定量TBIL >1 71 .1 μmol/L) 2 2例。 2例发展为亚急性重型肝炎 (7.7% ) ,入院时两组GGT、ALP、TBIL、DBIL、A/G比较 ,均P <0 .0 1 ,有显著性差异。结论甲亢合并戊肝患者消化道症状重 ,较易出现肝内胆汁淤积及高胆红素血症。甲亢合并戊肝患者的病程长 ,但经积极治疗甲亢并予一般的保肝、护肝、退黄与支持治疗 ,病情恢复较为理想。
Objective To analyze the clinical features of hyperthyroidism combined with hepatitis E. Methods Twenty-six patients with hyperthyroidism and hepatitis E were selected as observation group. Thirty patients with viral hepatitis E were randomly selected as control group. After admission, venous blood was taken and liver function was measured. Clinical symptoms, signs, liver Damage to laboratory indicators change and outcome. Results from the clinical manifestations, the observation group had fatigue, anorexia, nausea, abdominal distension and other obvious gastrointestinal symptoms in 9 cases, compared with the control group. There were 13 cases of skin itching and gray white, high jaundice (serum total bilirubin quantitative TBIL> 71 .1 μmol / L) 22 cases. 2 cases developed subacute severe hepatitis (7.7%). There were significant differences in GGT, ALP, TBIL, DBIL and A / G between the two groups when they were admitted to hospital (P <0.01). Conclusions Hyperthyroidism with hepatitis E patients with severe gastrointestinal symptoms, prone to intrahepatic cholestasis and hyperbilirubinemia. Hyperthyroidism with hepatitis E patients with a longer duration, but after active treatment of hyperthyroidism and to the general liver, liver, yellow and supportive treatment, the recovery of the situation is ideal.