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采用不同的实验性胃溃疡模型以探讨沙棘子油的药理作用,结果发现,十二指肠或灌胃给予沙棘子油100mg·kg-1、200mg·kg-1、500mg·kg-1,能明显抑制幽门结扎引起的胃溃疡;其抑制率在70.5%～96.6%;一次灌胃上述剂量明显抑制利血平型和应激性胃溃疡,其抑制率分别在49.8%～62.9%,62.9%～87.0%;每天ig沙棘子油上述剂量,连续14d可使醋酸引起的大鼠胃溃疡明显减轻,其抑制率为28.5%～66.4%,而上述剂量使胃蛋白酶活性明显降低。在组胺刺激引起的高分泌状态下,200mg·kg-1、400mg·kg-1的沙棘子油明显降低胃液量和游离酸量以及胃蛋白酶活性。表明沙棘子油具有明显的抑制实验性胃溃疡的作用,这种作用主要是通过抑制胃蛋白酶的活性和降低游离酸实现的。
Different experimental gastric ulcer models were used to investigate the pharmacological effects of seabuckthorn seed oil. It was found that seabuckthorn oil 100 mg·kg-1, 200 mg·kg-1, 500 mg·kg-1 was administered to the duodenum or intragastrically. Gastric ulcer caused by pylorus ligation was significantly inhibited; its inhibitory rate was 70.5%-96.6%; one dose of the above dose significantly inhibited reserpine-type and stress-induced gastric ulcer, and the inhibition rates were 49.8%-62.9%, 62.9%, respectively. ~ 87.0%; ig sea buckthorn oil daily dose, acetic acid-induced rats gastric ulcer significantly reduced, the inhibition rate was 28.5% ~ 66.4%, and the above dose makes pepsin activity significantly reduced. Under high-secretion conditions induced by histamine stimulation, 200 mg·kg-1, 400 mg·kg-1 of sea buckthorn oil significantly reduced gastric juice volume and free acid amount and pepsin activity. It was shown that seabuckthorn seed oil has a significant inhibitory effect on experimental gastric ulcers. This effect is mainly achieved by inhibiting the activity of pepsin and reducing free acid.