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目的探讨尼莫地平-生理盐水液灌洗术野对脑血管挛痉的防治作用。方法采用前瞻性、小样本、随机对照、单盲研究方法,对脑损伤需行开颅手术减压或血肿清除的患者,按入院手术先后顺序分为对照组(生理盐水)、治疗组(尼莫地平-生理盐水液1:10、1:5)进行术野灌洗,术后第1、3、7、15天检测手术侧大脑中动脉平均血流速度(VmMCA)。结果治疗组术后第1、3、7、15天VmMCA低于对照组,具有极其显著性差异;A组、B组、C组术后第1、3、7、15天VmMCA均具有显著性差异。结论尼莫地平-生理盐水术野灌洗防治脑血管痉挛疗效显著,且1:5组较1:10组效果更为显著。
Objective To investigate the preventive and therapeutic effects of nimodipine-saline irrigation on cerebrovascular spasm. Methods A prospective, small sample, randomized controlled, single-blind study was performed. Patients undergoing craniotomy decompression or hematoma removal for brain injury were divided into control group (saline), surgical group Moiping - saline solution 1:10, 1: 5) laparotomy, and the mean arterial blood flow velocity (VmMCA) was measured on the 1st, 3rd, 7th and 15th day after operation. Results The VmMCA in the treatment group was significantly lower than that in the control group on the 1st, 3rd, 7th and 15th days after operation. VmMCA was significantly different on the 1st, 3rd, 7th and 15th days in the A, B and C groups difference. Conclusion The effect of nimodipine - saline irrigation in prevention and treatment of cerebral vasospasm is significant, and the effects of nimodipine - saline in 1: 5 group are more obvious than those in 1:10 group.