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目的:探讨立体定向适形放疗治疗不能行手术治疗晚期胆管癌的疗效。方法:不能行手术治疗晚期胆管癌患者32例,经皮经肝胆管穿刺引流术后行立体定向适形放疗,处方剂量300～600 cGy,等剂量曲线50%～90%覆盖计划靶区,照射总剂量3 000～4 800cGy。治疗1次/d,7～15 d完成治疗。结果:治疗后3个月完全缓解8例,部分缓解16例,无变化8例,总有效率75.0%。6,12,18,24个月生存率分别为93.8%,59.4%,50.0%,12.5%。结论:立体定向适形放疗结合经皮经肝胆管穿刺引流术是治疗晚期胆管癌的有效方法。
Objective: To investigate the efficacy of stereotactic conformal radiotherapy in the treatment of advanced cholangiocarcinoma. Methods: 32 cases of patients with advanced cholangiocarcinoma were not surgically treated with stereotactic radiotherapy after percutaneous transhepatic biliary drainage. The prescribed dose was 300-600 cGy and the isodose curve covered 50% -90% of the planned target area. The total dose of 3 000 ~ 4 800cGy. Treatment 1 / d, 7 ~ 15 d to complete the treatment. Results: After 3 months of treatment, complete remission was achieved in 8 cases, partial remission in 16 cases, no change in 8 cases and total effective rate of 75.0%. The survival rates at 6, 12, 18 and 24 months were 93.8%, 59.4%, 50.0% and 12.5% respectively. Conclusion: Stereotactic conformal radiotherapy combined with percutaneous transhepatic biliary drainage is an effective method for the treatment of advanced cholangiocarcinoma.