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目的评价老年患者无痛胃镜检查中麻醉药物使用的疗效和不良反应。方法分层随机选择2013年7月1日—2016年7月1日北京地区行胃镜检查的≥60岁老年患者1 800例,依据患者采用的麻醉用药分组:丙泊酚+舒芬太尼组(PS组)、依托咪酯+舒芬太尼组(ES组),比较2组患者心率、血压、血氧饱和度、麻醉效果、苏醒时间、呼吸抑制情况。结果调查对象平均年龄(68.5±9.4)岁,体重(58.3±15.7)kg,2组患者心率、血压、血氧饱和度、麻醉效果、苏醒时间、呼吸抑制情况差异均无统计学意义(均P>0.05),PS组低血压检出率高于ES组(χ~2=8.49,P=0.00)。结论老年患者行无痛胃镜术,丙泊酚复合舒芬太尼与依托咪酯复合舒芬太尼的麻醉效果均较好,但需预防患者出现低血压。
Objective To evaluate the efficacy and side effects of anesthetic use in elderly patients with painless gastroscopy. Methods Stratified Randomized July 1, 2013 - July 1, 2016 A total of 1 800 elderly patients aged 60 years or older who underwent gastroscopy in Beijing were enrolled in this study. Patients were divided into three groups based on anesthetic: propofol plus sufentanil (PS group) and etomidate + sufentanil group (ES group). The heart rate, blood pressure, oxygen saturation, anesthetic effect, wake time and respiratory depression were compared between the two groups. Results The average age of subjects (68.5 ± 9.4) and weight (58.3 ± 15.7) kg, heart rate, blood pressure, blood oxygen saturation, anesthesia, wakefulness and respiratory depression in the two groups were not significantly different > 0.05). The detection rate of hypotension in PS group was higher than that in ES group (χ ~ 2 = 8.49, P = 0.00). Conclusions Elderly patients underwent painless gastroscopy, propofol combined with sufentanil and etomidate combined with sufentanil anesthesia are better, but the need to prevent hypotension in patients.