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重症肌无力(MG)和Lambert Eaton综合征(LEMS),均是以神经肌肉传递障碍为特征的自身免疫性疾病,除有类似处外,两者的根本区别在于发病机理和治疗上.MG是在乙酰胆碱受体水平的突触后障碍,而LEMS则是由突触前膜缺陷所致.本文报道一例患者兼有较罕见的两种疾病的临床和神经生理特点.女性患者,80岁,以波动性眼、球部肌和肢体肌肉软弱无力就诊.除疲劳试验可激发肌无力外,神经系检查未见其他异常.腱反射迟缓.血清抗乙酰胆碱受体抗体(+).予以一种抗胆碱醋酶剂治疗
Myasthenia gravis (MG) and Lambert’s Eaton’s syndrome (LEMS) are all autoimmune diseases characterized by neuromuscular delivery disorders. The fundamental difference between the two, except for the similarities, lies in the pathogenesis and treatment. MG is Postsynaptic disorder at the acetylcholine receptor level, whereas LEMS is caused by presynaptic membrane defects.This article reports the clinical and neurophysiological characteristics of one patient with both rarer diseases.A female patient, 80 years old, with Fluctuating eyes, ball muscles and limb muscle weakness treatment. In addition to fatigue test can stimulate myasthenia gravis, neurological examination showed no other abnormalities .Tendon reflex slow. Serum anti-acetylcholine receptor antibody (+) .A kind of anti-gallbladder Alkaline enzyme treatment