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目的 :探讨幽门螺杆菌 (Hp)相关性十二指肠溃疡 (DU)患者的胃粘膜及血浆中胃泌素 (SS)、生长抑素(GAS)的变化及其意义。方法 :对 45例证实为Hp感染的DU患者 ,采用PPI三联疗法 ,1月后胃镜复查。同时采用放射免疫法检测治疗前后血浆和胃粘膜中GAS、SS的表达 ,并与对照组比较。结果 :治疗后①溃疡愈合率为 86 .7% ,Hp根除率达 91.1% ;②血浆和胃粘膜中GAS、SS含量与对照组差异无显著性 (P >0 .0 5 ) 。但两组的GAS、SS较治疗前差异均有显著性 (P <0 .0 1)。结论 :Hp感染后胃粘膜及血浆中GAS分泌增加、SS分泌减少 ,是引起DU的原因之一。Hp根除后GAS、SS均可恢复正常水平。
Objective: To investigate the changes of gastric mucosa and plasma gastrin (SS) and somatostatin (GAS) in Helicobacter pylori (Hp) -related duodenal ulcer patients and its significance. Methods: Forty-five patients with DU confirmed by Hp infection were treated with PPI triple therapy and gastroscopy after one month. At the same time, radioimmunoassay was used to detect the expression of GAS and SS in plasma and gastric mucosa before and after treatment, and compared with the control group. Results: After treatment, the healing rate of ulcer was 86.7% and the eradication rate of Hp was 91.1%. There was no significant difference in the contents of GAS and SS in plasma and gastric mucosa compared with the control group (P> 0.05). However, GAS and SS in both groups were significantly different from those before treatment (P <0.01). Conclusion: Hp infection in gastric mucosa and plasma GAS secretion increased, SS secretion decreased, is one of the causes of DU. After Hp eradication GAS, SS can return to normal levels.