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目的:探讨奥美拉唑四联根除Hp阳性消化性溃疡的临床疗效及安全性。方法:以128例消化性溃疡患者为研究对象,随机分为观察组和对照组各64例,观察组给予以奥美拉唑为主并联合左氧氟沙星、阿莫西林及果胶铋四联疗法进行治疗,对照组给予以雷尼替丁为主的四联疗法治疗,观察两组患者在治疗效果、溃疡愈合时间、Hp根除率、不良反应发生率等方面的差异。结果:观察组治愈率为95.31%,平均溃疡愈合时间为(7.69±3.18)天,Hp根除率为96.88%,不良反应发生率为4.69%;对照组治愈率为81.25%,平均溃疡愈合时间为(13.58±4.62)天,Hp根除率为84.38%,不良反应发生率为10.94%。观察组的治愈率和Hp根除率均显著高于对照组,平均溃疡愈合时间短于对照组,不良反应发生率小于对照组,差异均具有统计学意义(P<0.05)。结论:以奥美拉唑为主的四联疗法治疗Hp阳性消化性溃疡具有显著的效果,能够根除Hp,促进溃疡愈合,并且不良反应发生率低,安全性较高,具有较高的临床应用价值。
Objective: To investigate the clinical efficacy and safety of omeprazole quadruple radical eradication of Hp-positive peptic ulcer. Methods: A total of 128 patients with peptic ulcer were randomly divided into observation group (64 cases) and control group (64 cases). The observation group was given omeprazole combined with levofloxacin, amoxicillin and pectin bismuth quadruple therapy The control group was treated with ranitidine-based quadruple therapy. The differences between the two groups in the treatment effect, ulcer healing time, Hp eradication rate and the incidence of adverse reactions were observed. Results: The cure rate of the observation group was 95.31%, the average healing time of ulcer was (7.69 ± 3.18) days, the eradication rate of Hp was 96.88%, the incidence of adverse reactions was 4.69%; the cure rate of the control group was 81.25% (13.58 ± 4.62) days, Hp eradication rate was 84.38%, the incidence of adverse reactions was 10.94%. The cure rate and Hp eradication rate in the observation group were significantly higher than those in the control group. The mean ulcer healing time was shorter than that in the control group, and the incidence of adverse reactions was less than that in the control group. The differences were statistically significant (P <0.05). Conclusion: Omeprazole-based quadruple therapy has significant effect on Hp-positive peptic ulcer. It can eradicate Hp, promote ulcer healing, and the incidence of adverse reactions is low, the safety is high, and has a high clinical application value.