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目的探讨血清hs-CRP水平与脑出血患者出血量、病情、认知功能损害的关系。方法回顾性分析62例脑出血患者的临床资料,另选择健康体检者25例为对照组。检测患者及对照组血清hs-CRP水平;分析其与患者出血量、病情、认知功能的关系。结果脑出血患者第1天hs-CRP水平为(5.5±1.6)mg/L,第3天为(9.8±3.1)mg/L,第7天为(6.9±2.4)mg/L,不同时间点比较,差异有统计学意义(P<0.05)。第3天和第7天显著高于第1天,而第7天又显著低于第3天(P均<0.05)。对照组hs-CRP水平为(2.4±0.9)mg/L,显著低于脑出血患者(P<0.01)。患者血肿越大、NIHSS评分越高、存在认知功能障碍,则hs-CRP水平越高(P<0.01)。结论急性自发性脑出血患者在发病后CRP会发生动态变化,出血量越大、NIHSS评分越高,患者CRP水平也越高。
Objective To investigate the relationship between serum hs-CRP levels and the amount of bleeding, illness and cognitive impairment in patients with intracerebral hemorrhage. Methods The clinical data of 62 patients with cerebral hemorrhage were retrospectively analyzed. Another 25 healthy subjects were selected as the control group. The levels of serum hs-CRP in patients and control groups were detected. The relationship between them and the amount of bleeding, illness and cognitive function were analyzed. Results The level of hs-CRP was (5.5 ± 1.6) mg / L on the first day, (9.8 ± 3.1) mg / L on the third day and (6.9 ± 2.4) mg / L on the seventh day, The difference was statistically significant (P <0.05). Day 3 and day 7 were significantly higher than day 1, and significantly lower than day 3 on day 7 (all P <0.05). The level of hs-CRP in control group was (2.4 ± 0.9) mg / L, which was significantly lower than that in patients with intracerebral hemorrhage (P <0.01). The greater the patient’s hematoma, the higher the NIHSS score and the presence of cognitive impairment, the higher the hs-CRP level (P <0.01). Conclusion The incidence of CRP changes in patients with acute spontaneous cerebral hemorrhage after onset, the greater the amount of bleeding, the higher the NIHSS score, the higher the CRP level.