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微RNAs( miRNAs)目前被认为是缺氧的新型调控基因,它能调节基因表达并且参与许多正常细胞和肿瘤细胞的生理过程。研究表明,缺氧诱导因1(HIF1)能调控一系列miRNAs,同时一些miRNAs又以HIF1为靶基因。 miRNAs与HIF1相互作用与肿瘤相关,如血管生成、代谢、细胞凋亡、细胞周期调节、增殖转移和抗癌疗法。近年来研究表明,缺氧能调节miRNAs的表达,而miRNAs也参与肿瘤靶基因的调控,进而miRNAs在分子水平影响人类肿瘤细胞的代谢、凋亡、转移和治疗等。“,”MiRNAs are recognized as a new class of master regulators under hypoxia that control gene expression and are responsible for many normal and pathological cellular processes. Studies have shown that hypoxia inducible factor 1(HIF1) regulates a panel of miRNAs,whereas some of miRNAs target HIF1. The interaction between miRNAs and HIF1 can account for many vital events relevant to tumorigenesis,such as angiogenesis,metabolism,apoptosis,cell cycle regulation,proliferation,metastasis,and resistance to antican-cer therapy. Recently, a few reports revealed that hypoxia regulates the expression of miRNAs, which are involved in tumor target gene regulation,thus influence a wide variety of human tumors on molecular level, such as metabolism,apoptosis,metastasis and treatment.