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目的研究弥漫大B细胞淋巴瘤患者血浆D-二聚体水平与DLBCL临床预后指标的关系。方法采用ELISA法检测50例DLBCL患者及对照组20例淋巴结反应性增生(RH)患者血浆D-二聚体的水平。结果 DLBCL患者血浆D-二聚体显著高于对照组水平(P=0.012),并且D-二聚体与LDH及β2-微球蛋白水平呈正相关,存在B症状的患者血浆表达D-二聚体显著高于无B症状组,其表达差异根据患者年龄、临床分期及结外病变不同无统计学意义。结论DLBCL患者血浆D-二聚体水平反映了病情变化,并从一定程度对预后进行判断,同时为尽早预防并发现血栓提供一定的依据。
Objective To study the relationship between plasma D-dimer level and the clinical prognosis of DLBCL in patients with diffuse large B-cell lymphoma. Methods The levels of plasma D-dimer in 20 patients with reactive lymph node-reactive hyperplasia (RH) from 50 patients with DLBCL and those from the control group were detected by ELISA. Results The level of plasma D-dimer in patients with DLBCL was significantly higher than that in controls (P = 0.012), and there was a positive correlation between D-dimer and LDH and β2-microglobulin levels in patients with B symptoms Body was significantly higher than the group without B symptoms, the expression differences according to patient age, clinical stage and extranodal disease was not statistically different. Conclusion The plasma D-dimer levels in patients with DLBCL reflect the changes of the disease, and to a certain extent, to determine the prognosis, and provide a basis for the prevention and detection of thrombus as soon as possible.