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腺病毒载体是目前最有应用前景的疫苗载体之一,具有高表达、可同时诱导特异性体液免疫和细胞免疫反应、安全性好、易于制备、无需添加佐剂等优点,被广泛应用于各种预防性或治疗性疫苗的研发。本文就进入临床试验的重要腺病毒载体疫苗作一综述。
Adenovirus vectors are currently one of the most promising vaccine vectors with high expression, which can induce specific humoral and cellular immune responses at the same time. The adenovirus vectors are safe, easy to prepare and have no need to add adjuvants. They are widely used in Preventive or therapeutic vaccine development. This article reviews the important adenoviral vectors that enter clinical trials.