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目的探讨2型糖尿病患者糖化血红蛋白(HbA1c)与全天不同时间血糖水平的关系。方法171例2型糖尿病患者检测三餐前30min、餐后2h及晚睡前共7次血糖水平,并计算平均血糖水平(MBG),同时测定HbA1c。按HbA1c水平不同将患者分为2组血糖控制尚可组(HbA1c≤7.5%)和控制差组(HbA1c>7.5%)。直线回归相关分析总体及各组HbA1c与MBG、全天7次血糖的相关性。结果MBG与HbA1c呈显著正相关(r=0.851,P<0.001),MBG=-0.70+1.30×HbA1c;HbA1c与全天7次血糖水平均呈正相关,逐步多元线形回归分析示HbA1c与空腹、晚餐后、午餐后及早餐后血糖相关。HbA1c≤7.5%组的HbA1c与晚餐后、午餐后及午餐前血糖相关,而HbA1c>7.5%组HbA1c与空腹、晚餐后、午餐后及早餐后血糖相关。结论HbA1c受全天平均血糖水平的影响,血糖控制尚可组晚餐后、午餐后及午餐前的血糖对HbA1c影响明显,而血糖控制差组空腹、晚餐后、午餐后及早餐后的血糖对HbA1c影响明显。
Objective To investigate the relationship between glycosylated hemoglobin (HbA1c) and blood glucose level in patients with type 2 diabetes at different times of the day. Methods 171 patients with type 2 diabetes mellitus were tested for blood glucose levels 30 minutes before meals, 2 hours after meal and 7 times before going to sleep. Mean blood glucose level (MBG) was calculated and HbA1c was also measured. Patients were divided into two groups according to the level of HbA1c: HbA1c≤7.5% and control group (HbA1c> 7.5%). Linear regression analysis of the overall and groups HbA1c and MBG, seven times a day blood glucose correlation. Results There was a significant positive correlation between MBG and HbA1c (r = 0.851, P <0.001) and MBG = -0.70 + 1.30 × HbA1c. There was a positive correlation between HbA1c and blood glucose level 7 times a day. Multiple linear regression analysis showed that HbA1c was associated with fasting, After, after lunch and after breakfast related to blood sugar. HbA1c in HbA1c≤7.5% group was associated with postprandial blood glucose before lunch and after lunch, while HbA1c with HbA1c> 7.5% was associated with fasting, postprandial, postprandial and postprandial blood glucose. Conclusions HbA1c is affected by the average daily blood glucose level. The blood sugar control is still available in group after dinner. The blood sugar after lunch and before lunch has a significant effect on HbA1c. However, the fasting, postprandial, postprandial and post- Significant impact.