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目的探讨女性生殖系统多原发恶性肿瘤(MPMN)的临床病理特征、诊治和预后。方法对2008年1月至2014年12月于四川大学华西第二医院妇产科就诊的48例女性生殖系统MPMN患者的临床病理资料进行回顾性分析。结果 48例患者中,同时性MPMN 42例,异时性MPMN 6例,中位年龄44岁;子宫内膜并发卵巢恶性肿瘤占56.3%(27/48),其中74.1%(20/27)的患者两癌均为子宫内膜样腺癌;47例患者行根治性手术治疗,1例未手术行化疗,47例行手术治疗的患者中40例术后进行化疗或放疗等辅助治疗;随访4~84个月,健在41例,死亡3例,失访4例,随访率90.7%。结论女性生殖系统的多原发恶性肿瘤以子宫内膜并发卵巢恶性肿瘤最为常见,早期诊断,以手术为主的综合治疗,定期复诊,对改善患者预后具有积极作用。
Objective To investigate the clinicopathological features, diagnosis, treatment and prognosis of female reproductive system multiple primary malignant tumors (MPMN). Methods The clinical and pathological data of 48 female reproductive system MPMN patients attending obstetrics and gynecology department of West China Second Hospital of Sichuan University from January 2008 to December 2014 were analyzed retrospectively. Results Among the 48 patients, 42 cases were concurrent MPMN and 6 cases were allochronic MPMN. The median age was 44 years. The incidence of endometrial malignant ovarian cancer was 56.3% (27/48), of which 74.1% (20/27) Forty-seven patients underwent radical surgery, one without chemotherapy, and forty-seven patients underwent adjuvant chemotherapy or radiotherapy after surgery. Follow-up 4 ~ 84 months, alive in 41 cases, 3 died, 4 cases were lost, the follow-up rate was 90.7%. Conclusions The multiple primary malignant tumors of the female reproductive system are the most common and early diagnosis of endometrial malignancy with ovarian cancer. The comprehensive treatment based on surgery and regular referral have a positive effect on the prognosis of patients.