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目的探讨心钠素与脑梗塞间的关系，为脑梗塞的防治提供新的理论依据。方法在１Ｗｋ内及２ｗｋ后分别同步采取脑梗塞患者及对照者空腹血浆及ＣＳＦ标本．处理后－２０℃冰冻保存．用γ－计数测定其中ＡＮＰ含量及变化情况．结果正常对照组血及ＣＳＦ中ＡＮＰ含量分别为５０．３７±１７．２９和４７．０８±１６．６０ｎｇ·Ｌ－１．备性脑梗塞（ＩＷｋ内）血浆及ＣＳＦ中ＡＮＰ含量分别为６８．４３±１５．７４和５６．４５±１１．２２ｎｇ·Ｌ－１，明显高于对照组（Ｐ＜０．０１）．结论急性脑梗塞患者血浆及ＣＳＦ中ＡＮＰ含量增高可能与脑梗塞的病理生理机制有关．
Objective To explore the relationship between atrial natriuretic peptide and cerebral infarction and to provide a new theoretical basis for the prevention and treatment of cerebral infarction. Methods Fasting plasma and CSF samples from patients with cerebral infarction and controls were taken simultaneously within 1wk and 2wk respectively. After treatment frozen at -20 ℃. The content of ANP and its changes were determined by γ-count. Results The levels of ANP in the blood and CSF of the normal control group were 50.37 ± 17.29 and 47.08 ± 16.60 ng · L -1, respectively. The levels of ANP in plasma and CSF of prepared cerebral infarction (IWk) were 68.43 ± 15.74 and 56.45 ± 11.22ng · L-1, respectively, which were significantly higher than that of the control group (P <0.01). Conclusion The increase of ANP in plasma and CSF of patients with acute cerebral infarction may be related to the pathophysiological mechanism of cerebral infarction.