对２１９例咨询病人的外周血细胞做了Ｇ带染色体分析，发现异常核型３１例，占１４．２％，其中临床诊断少儿智力低下的异常率最高，达３８．２％，男性不育症的异常率亦高达１８．５％，而少儿性别发育异常、不良生育史及自发性流产的核型异常率相对较低，３．３％～１５．３％． G-band chromosome analysis of peripheral blood cells of 219 patients was performed. There were 31 cases of abnormal karyotype, accounting for 14.2%. Among them, the abnormal rate of clinical diagnosis of mental retardation in children was the highest (38.2%), male infertility The abnormal rate was as high as 18.5%. However, the rate of karyotypic abnormalities in children with genital dysplasia, poor reproductive history and spontaneous abortion was relatively low, ranging from 3.3% to 15.3%.