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免疫球蛋白(下称Ig)是由B 细胞经抗原刺激后,转化为浆细胞合成分泌的一种有抗体活性的蛋白质,所谓Ig 异常系指Ig 含量增加、减少或分子结构异常。由Ig 异常直接造成的疾病称之为Ig 分子病,包括重链病、轻链病、半分子病等。严格地讲,多发性骨髓瘤、巨球蛋白血症、原发性丙球蛋白缺陷症等也应属于Ig 分子病。Ig 由多种B 细胞转化成浆细胞产生,各个细胞
Immunoglobulin (hereinafter referred to as Ig) is a kind of antibody that is synthesized and secreted by plasma cells after the B cells are stimulated by antigen, and the so-called Ig abnormality refers to the increase, decrease or molecular structure abnormality of Ig. Diseases caused by an abnormal Ig directly called Ig molecular disease, including heavy chain disease, light chain disease, semi-molecular disease. Strictly speaking, multiple myeloma, macroglobulinemia, primary globulin deficiency, etc. should also belong to Ig molecular disease. Ig from a variety of B cells into plasma cells, each cell