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目的 探讨大肠癌组织中27E10阳性巨噬细胞(Mφ)浸润程度与大肠癌临床病理特征及预后的关系。方法 采用免疫组化SP法对60例大肠癌患者癌组织中的27E10阳性Mφ进行检测,并分析其与大肠癌的组织学类型、癌的浸润深度、淋巴结转移及患者生存率之间的关系。结果 27E10阳性Mφ高计数组的癌浸润深度、淋巴结及远处转移发生率均低于低计数组(P均<0.05)。27E10阳性Mφ高计数组的5年生存率为62.1％,明显高于低计数组的35.5％(P<0.05)。结论 癌组织中27E10阳性Mφ浸润的数量与大肠癌的生物学行为有关,对大肠癌患者的预后评估有较大参考价值。
Objective To investigate the relationship between the degree of infiltration of 27E10-positive macrophages (Mφ) and the clinicopathological characteristics and prognosis of colorectal cancer in colorectal cancer. Methods The immunohistochemical SP method was used to detect the 27E10 positive Mφ in 60 cases of colorectal cancer and its relationship with histological type, depth of cancer invasion, lymph node metastasis and patient survival rate were analyzed. Results The depth of invasion, lymph node metastasis and distant metastasis in 27E10-positive Mφ high count group were lower than those in low count group (all P <0.05). The 5-year survival rate of the 27E10-positive Mφ high-count group was 62.1%, significantly higher than that of the low-count group 35.5% (P <0.05). Conclusion The number of 27E10-positive Mφ in cancerous tissues is related to the biological behavior of colorectal cancer, which is of great value to the prognosis evaluation of patients with colorectal cancer.