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目的研究探讨窒息新生儿生后早期振幅整合脑电图(aEEG)的临床表现及特点。方法 50例窒息新生儿作为观察组,同期50例健康新生儿作为对照组,均在出生后的6 h内对其进行早期aEEG监测,观察其背景活动、睡眠-觉醒周期(SWC)以及痫性活动特点,并对各指标与患儿窒息程度、脑损伤程度之间的相互关系进行分析。结果观察组新生儿aEEG监测结果中背景活动异常率为42.0%、无SWC率为12.0%、痫性活动发作率为20.0%显著高于对照组的0、0、0,且有重度窒息新生儿同时高于轻度窒息新生儿的情况,差异有统计学意义(P<0.05)。统计不同严重程度的缺血缺氧性脑病新生儿的aEEG表现,可见轻、中、重度患儿比较,差异有统计学意义(P<0.05)。结论通过早期aEEG可以对窒息新生儿的脑损伤情况进行及时诊断,为临床治疗干预提供依据,具有临床推广和应用价值。
Objective To study the clinical manifestations and characteristics of amplitude-integrated electroencephalography (aEEG) in neonates with asphyxia after neonatal asphyxia. Methods Fifty asphyxia neonates were selected as the observation group and 50 healthy newborns at the same period as the control group. All of them were monitored by aEEG within 6 hours after birth, and their background activities, sleep-wake cycle (SWC) Activity characteristics, and the indicators and the degree of suffocation in children, the degree of brain damage between the correlation analysis. Results The aEEG monitoring results of observation group showed abnormal background activity rate of 42.0%, no SWC rate of 12.0%, seizure activity rate of 20.0%, significantly higher than the control group of 0,0,0, and severe asphyxia neonates At the same time higher than mild asphyxia newborns, the difference was statistically significant (P <0.05). Statistical analysis of aEEG of neonates with different severity of hypoxic-ischemic encephalopathy showed that the difference was statistically significant (P <0.05). Conclusion Early aEEG can diagnose neonatal asphyxial brain injury in time and provide a basis for clinical treatment intervention, which has clinical application and promotion value.