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目的探讨2型糖尿病(T2DM)患者尿mindin与糖尿病肾病(DN)的关系。方法采用ELISA法测定90例T2DM患者(A组)和32例健康体检者(B组)尿mindin水平。依据尿白蛋白/尿肌酐相对值(ACR)水平,A组再分为无蛋白尿(A1组)、微量蛋白尿(A2组)和大量蛋白尿(A3组)三个亚组。检测并分析相关指标。结果 A组患者尿mindin相对值(MCR=尿mindin/尿肌酐)与尿微量蛋白、糖化血红蛋白、收缩压、病程、血肌酐和24-h尿蛋白呈正相关(P<0.05或P<0.01),与肾小球滤过率呈负相关(r=-0.395,P<0.01)。慢性肾脏病分期为1、2、3期患者的尿MCR递增:3期(16例)>2期(45例)>1期(24例)(P<0.01),且与ACR变化规律类似。结论尿mindin可能与T2DM患者肾损伤密切有关;联合检测尿mindin和尿微量白蛋白有助于发现早期DN。
Objective To investigate the relationship between urinary mindin and diabetic nephropathy (DN) in type 2 diabetes mellitus (T2DM). Methods The urinary mindin levels in 90 T2DM patients (group A) and 32 healthy subjects (group B) were measured by ELISA. According to the level of urinary albumin / creatinine (ACR), group A was subdivided into three subgroups: proteinuria (group A1), microalbuminuria (group A2) and proteinuria (group A3). Detection and analysis of relevant indicators. Results The relative value of urinaryin (MCR = urine mindin / urinary creatinine) in group A was positively correlated with urinary protein, glycosylated hemoglobin, systolic blood pressure, duration of disease, serum creatinine and 24-h urinary protein (P <0.05 or P <0.01) And glomerular filtration rate was negatively correlated (r = -0.395, P <0.01). Urinary MCR was increased in patients with stage 1, 2, and 3 chronic renal disease (stage 3, 16, 2, 45, 1, and 24) Conclusions Urine mindin may be closely related to renal damage in T2DM patients. Combined detection of urine mindin and urinary microalbumin can help detect early DN.