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目的研究策乳酸籽子（PLAM）对异基因抵抗作用的抑制作用。方法于异基因骨髓移植前不同时间静脉络以不同剂量PLAM，测定移植受体的存活时间以及移植受体day9和day14CFU－S的形成．结果移植前胸静脉注射PLAM：0.75g·kg-1体全可明显促进移植受体day9和day14CFU-S的形成，同时明显延长移植受体的存活时间，而低于该剂量或在移植前2或24h静脉注射PLAM则无效，当静脉注射PLAM1g·kg－1体重以上时，则可同时促进内源性CFU－S的形成。结论吞噬细胞与异基因骨髓移植时存在的异基因抵抗效应密切相关；一定剂量的PLAM于移植前一定时间静脉注射给移植受体可明显减轻异基因抵抗效应，延长移植受体的存活时间；大剂量PLAM静脉注射可提高机体的辐射抵抗能力。
Objective To study the inhibitory effect of PLAM on allogenetic resistance. METHODS: Different doses of PLA were intravenously administrated at different times before allogeneic bone marrow transplantation. The survival time of transplant recipients and the formation of day9 and day14CFU-S transplant recipients were measured. RESULTS: Pre-transplantation of PLAM at the thoracic vein of 0.75 g·kg-1 body all significantly promoted the formation of day9 and day14CFU-S receptors and significantly prolonged the survival time of transplant recipients, which was lower than the dose or before transplantation. Intravenous injection of PLAT for 24 hours is not effective. When intravenously injecting PLAG at a body weight of 1 g·kg-1 or more, it can promote the formation of endogenous CFU-S. Conclusion The phagocytic cells are closely related to the allogeneic resistance effect of allogeneic bone marrow transplantation. A certain dose of PLA injecting intravenously to transplant recipients for a certain period of time can significantly reduce allogeneic resistance and prolong the survival time of transplant recipients; Dosage PLAM intravenous injection can improve the body’s radiation resistance.